Personally I like to split my poker rooms into 2 groups, European based rooms & American based rooms and play to their night times. Especially at weekends when many drunk gamblers come online
I find the end of the month can be quite rewarding too when the gamblers get their monthly wages paid in to their bank accounts
I suspect there's a 3rd group I could add, Asian & Australian but unfortunately they dont suit my hours
At the end of the day, you can never have too many poker rooms to choose from and some rooms are going to be more profitable at certain hours of the day compared to other rooms.